Primary Cutaneous Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Mimicking Malignant Eccrine Spiradenoma with 22q12 Translocation by Interphase Fluorescent in Situ Hybridization
Identifieur interne : 008199 ( Main/Exploration ); précédent : 008198; suivant : 008200Primary Cutaneous Ewing’s Sarcoma/Primitive Neuroectodermal Tumor Mimicking Malignant Eccrine Spiradenoma with 22q12 Translocation by Interphase Fluorescent in Situ Hybridization
Auteurs : R. M. Patel [États-Unis] ; J. R. Goldblum [États-Unis] ; M. Skacel [États-Unis] ; E. Downs-Kelly [États-Unis] ; R. Tubbs [États-Unis] ; C. Embi [États-Unis] ; W. F. Bergfeld [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Cutaneous small blue cell tumors are relatively uncommon neoplasms whose differential includes primary adnexal, neuroendocrine and lymphoproliferative tumors, as well as metastatic lesions. Another entity to be considered in the differential is Ewing’s sarcoma (ES)/primitive neuroectodermal tumor (PNET). We present a 19‐year‐old female who developed a solitary, subcutaneous mass on her back. Histology revealed a poorly differentiated, cellular, nodular neoplasm of small, blue cells containing round to ovoid, vesicular nuclei with indistinct nucleoli and scant eosinophilic cytoplasm. Tumor cells were strongly immunoreactive for antibodies to carcinoembryonic antigen (CEA), Cam 5.2 and CD99. Overall, the lesion resembled an malignant spiradenoma (spiradenocarcinoma). CD99 reactivity prompted analysis with dual‐color interphase FISH for translocations involving (22q12), which was positive, a sensitive marker for ES/PNET. Our case demonstrates that a diagnosis of ES/PNET should be considered in the differential of primary cutaneous blue cell tumors. These lesions are difficult to distinguish from other cutaneous small blue cell tumors due to their rarity and because the diagnosis is often not considered at this site.
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DOI: 10.1111/j.0303-6987.2005.320fi.x
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M." last="Patel">R. M. Patel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Goldblum, J R" sort="Goldblum, J R" uniqKey="Goldblum J" first="J. R." last="Goldblum">J. R. Goldblum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Skacel, M" sort="Skacel, M" uniqKey="Skacel M" first="M." last="Skacel">M. Skacel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Downs Elly, E" sort="Downs Elly, E" uniqKey="Downs Elly E" first="E." last="Downs-Kelly">E. Downs-Kelly</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Tubbs, R" sort="Tubbs, R" uniqKey="Tubbs R" first="R." last="Tubbs">R. Tubbs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Embi, C" sort="Embi, C" uniqKey="Embi C" first="C." last="Embi">C. Embi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Bergfeld, W F" sort="Bergfeld, W F" uniqKey="Bergfeld W" first="W. F." last="Bergfeld">W. F. Bergfeld</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Pathology, Emory University, Atlanta, GA; Divisions of Pathology and Laboratory Medicine and Dermatology, The Cleveland Clinic Foundation, Cleveland</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="108">108</biblScope><biblScope unit="page-count">2</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous small blue cell tumors are relatively uncommon neoplasms whose differential includes primary adnexal, neuroendocrine and lymphoproliferative tumors, as well as metastatic lesions. Another entity to be considered in the differential is Ewing’s sarcoma (ES)/primitive neuroectodermal tumor (PNET). We present a 19‐year‐old female who developed a solitary, subcutaneous mass on her back. Histology revealed a poorly differentiated, cellular, nodular neoplasm of small, blue cells containing round to ovoid, vesicular nuclei with indistinct nucleoli and scant eosinophilic cytoplasm. Tumor cells were strongly immunoreactive for antibodies to carcinoembryonic antigen (CEA), Cam 5.2 and CD99. Overall, the lesion resembled an malignant spiradenoma (spiradenocarcinoma). CD99 reactivity prompted analysis with dual‐color interphase FISH for translocations involving (22q12), which was positive, a sensitive marker for ES/PNET. Our case demonstrates that a diagnosis of ES/PNET should be considered in the differential of primary cutaneous blue cell tumors. These lesions are difficult to distinguish from other cutaneous small blue cell tumors due to their rarity and because the diagnosis is often not considered at this site.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Patel, R M" sort="Patel, R M" uniqKey="Patel R" first="R. M." last="Patel">R. M. Patel</name></region><name sortKey="Bergfeld, W F" sort="Bergfeld, W F" uniqKey="Bergfeld W" first="W. F." last="Bergfeld">W. F. Bergfeld</name><name sortKey="Downs Elly, E" sort="Downs Elly, E" uniqKey="Downs Elly E" first="E." last="Downs-Kelly">E. Downs-Kelly</name><name sortKey="Embi, C" sort="Embi, C" uniqKey="Embi C" first="C." last="Embi">C. Embi</name><name sortKey="Goldblum, J R" sort="Goldblum, J R" uniqKey="Goldblum J" first="J. R." last="Goldblum">J. R. Goldblum</name><name sortKey="Skacel, M" sort="Skacel, M" uniqKey="Skacel M" first="M." last="Skacel">M. Skacel</name><name sortKey="Tubbs, R" sort="Tubbs, R" uniqKey="Tubbs R" first="R." last="Tubbs">R. Tubbs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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